Pharmaceutical Drug

Detail:
It is used for the treatment of hepatitis C virus (HCV) infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon, an injectable drug with severe side effects. that is a key component of older drug combinations for the treatment of HCV.

Dosage and Administration:
The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice.

Marketed By: “Abbott“ ;
Indian Brand – “Ledviclear” ;
Active Ingredient(s) –  “Sofosbuvir And Ledipasvir” ;
Strength – “400mg And 90mg” ;
Dosage Form – “Tablet” ;
Package Size – “28 Tabs” ;
Package Type – “Plastic Bottle” ;
Expiry – “1 Year to 2 Years” ;
Indication(s) – “Hepatitis C Virus (HCV) Infection” ;
UPC / GTIN Barcode – “No” ;
Prescription Required – “Yes” ;

Ledviclear 90mg/400mg Tablet is a combination of two antiviral medicines: Ledipasvir and Sofosbuvir.

Ledipasvir and sofosbuvir are antiviral medications that prevent the hepatitis C virus (HCV) from multiplying in your body. Ledviclear is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Each Tablet of Ledviclear Is Contain 90mg of Ledipasvir And 400mg of Sofosbuvir.

Ledviclear Tablets Side Effects:

• Tiredness,
• A headache,
• Nause 
• Diarrhea
• A cough
• Irritability
• Muscle pain
• Dizziness and many more

A patient, apart from the common side effects, may also possess some serious side effects, few being: 

• Rashes
• Face swelling
• Arms and legs swelling
• Breathing problems
• Blisters and many more

Ledviclear Tablets Precautionary Measures: 

• If you are allergic to sofosbuvir or ledipasvir or any other medicine or ingredient, do tell your doctor
• If you are taking any other prescription, non-prescription medicines, vitamins, supplements or any kind of herbal product, do tell your doctor.
• If you are consuming magnesium hydroxide or antacids containing aluminium hydroxide, take them at least 4 hours before or after taking ledipasvir and sofosbuvir. 
• Be cautious with medicine if you are pregnant, breastfeeding or planning to become pregnant. 

Virso 400mg Tab 28s Salt Information :
Uses of Virso 400mg Tab 28s:

Sofosbuvir is a prescription medicine used with other antiviral medicines to treat chronic (lasting a long time) hepatitis C (Hep C) infection in adults.
Side Effects of Virso 400mg Tab 28s:

For Sofosbuvir used in combination with ribavirin they include tiredness and headache and for Sofosbuvir used in combination with peginterferon alfa and ribavirin they include the additional side effects of nausea, difficulty sleeping, and low red blood cell count.
Drug Interactions of Virso 400mg Tab 28s:

If you have: liver problems other than hepatitis C infection; had a liver transplant; severe kidney problems or are on dialysis; HIV; any other medical condition; or if you are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take Sofosbuvir or breastfeed. You should not do both. If you take amiodarone Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how Sofosbuvir works.
Contraindications of Virso 400mg Tab 28s:
When used in combination with peginterferon alfa/ribavirin or ribavirin alone, all contraindications to peginterferon alfa and/or ribavirin also apply to Sofosbuvir combination therapy.
Mechanism of Action of Virso 400mg Tab 28s:
Sofosbuvir inhibits the RNA polymerase that the hepatitis C virus uses to replicate its RNA. It was discovered at Pharmasset and developed by Sciences.
Special Precautions for Virso 400mg Tab 28s:
Bradycardia with amiodarone coadministration: Serious symptomatic bradycardia may occur in patients taking amiodarone and Sofosbuvir in combination with another direct acting antiviral (DAA), particularly in patients also receiving beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease. Coadministration of amiodarone with Sofosbuvir in combination with another DAA is not recommended. In patients without alternative, viable treatment options, cardiac monitoring is recommended. Pregnancy: Ribavirin may cause birth defects and fetal death and animal studies have shown interferons have abortifacient effects; avoid pregnancy in female patients and female partners of male patients. Patients must have a negative pregnancy test prior to initiating therapy, use at least 2 effective methods of contraception and have monthly pregnancy tests.